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KMID : 1134819980270020326
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Journal of the Korean Society of Food Science and Nutrition
1998 Volume.27 No. 2 p.326 ~ p.332
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The Effect of Mushroom Extracts on Carbon Tetrachloride - Induced Hepatotoxicity in Rats
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Kim Gun-Hee
Han Hye-Kyoung
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Abstract
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The effect of mushroom extracts from Pleurotus ostreatus and Lentinus edodes on carbon tetrachloride(CCl₄)-induced hepatotoxicity was investigated. Rats were administered orally each mushroom extract at the dose of l50㎎/㎏, followed by treatment with CCl₄. Liver damage was produced in male Sprague-Dawley rats, after 21hrs from dosing with CCl₄(0.25ml/㎏) which were given intraperitoneally. Liver damage without renal injury was confirmed by measuring plasma enzyme, creatinine and blood urea nitrogen levels. We examined the effect of mushroom extracts on liver damage by blood chemical analysis and liver analysis. Plasma aminotransferase activity, and levels of cholesterol and triglyceride were analyzed. Plasma alanine aminotransferase and aspartate aminotransferase activities were decreased by 34% and 61.5% in pretreatment group of Lentinus edodes compared with CCl₄ treated group, respectively. The adminstration of all mushroom extracts led the plasma cholesterol and triglyceride levels decrease more than the CCl₄-treated rats. These results suggest that Lentinus edodes extract protect liver from damage induced by CCl₄.
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KEYWORD
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Pleurotus ostreatus, Lentinus edodes, carbon tetrachloride(CCl4)-induced hepatotoxicity, blood chemical analysis
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